FORMULATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE LOADED TRANSFEROSOMAL GEL BY THIN FILM HYDRATION TECHNIQUE
نویسندگان
چکیده
Objective(s): The current studys goal is to develop and test a tramadol hydrochloride transdermal gel based on vesicular drug delivery approaches. Materials methods: Transferosomes were chosen as the colloidal carrier for preparation. Thin film hydration was used create transferosomes. obtained transferosomes characterised content, diameter, zeta potential, entrapment efficiency, invitro release studies. Results: T5 (made via thin comprising soya lecithin: Tween 60 ratio of 1:2.5) deemed best transferosome formulation due its 274.2nm mean -29.5 mV 93.9% 97% 92.7% sustained after 12 hours. included into gel. There comparison between plain transfersomal Transfersomal rated superior other gels higher concentration (91%), spreadability (18.35 g.cm/sec), pH (6.9), profile over Conclusion: By comparing transferosomal with indicated better results than
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ژورنال
عنوان ژورنال: International journal of advanced research
سال: 2022
ISSN: ['2707-7802', '2707-7810']
DOI: https://doi.org/10.21474/ijar01/15881