FORMULATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE-LOADED NIOSOMAL GEL BY ETHER INJECTION METHOD

Objective: The primary goal of this study was to develop a topical gel containing tramadol hydrochloride-loaded Niosomes injection technique as the vesicular carrier for site-specific delivery. Methods: niosomes were created by varying ratios nonionic surfactants (Tween 80, Tween 60, 20, Span and 80) cholesterol while keeping drug concentration constant. Results Discussion: Each formulation examined content, entrapment efficiency, mean diameter, zeta potential, in-vitro release tests. Among six formulations, N2 20 demonstrated maximal content 96.7%, efficiency 99%, diameter 319 nm, potential −28 mV, 90.14% in 12 h, followed zero-order with non-fickian diffusion mechanism ether method. As result, approach is an optimal procedure synthesis hydrochloride niosomes. Conclusion: By comparing Niosomal plain indicated better results than gel.