Formulation and evaluation of oral disintegrating tablets of furosemide

Orally disintegrating tablets of Furosemide were prepared, evaluated and the comparison action different concentrations disintegrants on disintegration dissolution studied. Direct compression method was used to prepare orally containing 20 mg Furosemide. The formulation conducted using crospovidone, croscarmellose sodium starch glycolate as superdisintegrants their interactions with also FTIR. FTIR studies drug its mixtures excipients showed that peaks correlate one another which signify there is no interaction between molecule used. obtained results revealed time ODTs 9 59 seconds. percentage content in all formulations found 91.51% 106.69%, complies limits established pharmacopoeia. in-vitro show maximum release 89.47% F3 minimum 77.64% F12. Higher concentration crospovidone F6 better properties than SSG. So by varying superdisintegrants, oral can be formulated.