Formulation and Evaluation of an Anti-inflammatory Topical Polyherbal Gel

Inflammation is currently treated with NSAIDs. Unfortunately, these drugs increase the risk of blood clots, heart attacks, and strokes. Therefore, development potent anti-inflammatory from natural products being investigated. Natural made medicinal plants play an important role in curing many diseases associated inflammation. Conventional drug available market has various side effects. Because effects, there a need to look for newer fewer or no The objective present study was develop polyherbal gel containing hydroalcoholic extract Berberis aristata root, Rubia cordifolia root Boswellia serrata gum by using Carbopol 934 Propylene glycol. 32 factorial design constructed concentration polymer (carbopol 934) penetration enhancer (Propylene glycol) as independent variables while Viscosity (m.Pas), % vitro release Berberine, Rubiadin AKBA dependent variables, total 9 possible experimental runs formulate evaluate. optimized selected expert employing overlay plot desirability approach. Optimized showed 39568 m.Pas viscosity, content Berberine 0.48 mg, 0.42 mg 0.51 mg. In vivo histopathology revealed that prepared good activity.