Formulation and Characterization of Felodipine as an Oral Nanoemulsions

Felodipine is a calcium-channel blocker with low aqueous solubility and bioavailability. Lipid dosage forms are attractive delivery systems for such hydrophobic drug molecules. Nanoemulsion (NE) one of the popular methods that has been used to solve dispersibility problems many drugs. was formulated as NE utilizing oleic acid an oil phase, tween 80 60 surfactants ethanol co-surfactant. Eight formulas were prepared, different tests performed ensure stability NEs, particle size, polydispersity index, zeta potential, dilution test, content, viscosity in-vitro release. Results characterization showed felodipine nanoemulsion (F3) (oleic 10%) ,(Smix 60% tween80 :ethanol in ratio 3:1), (DDW 30%) selected best formula, since it size (17.01)nm, PDI (0.392), potential (-22.34mV), good without precipitation , higher percent content (99.098%) acceptable complete release after (45 min.) significantly (P<0.05) dissolution rate comparison pure powder. The formula subjected further investigations excipient compatibility study by Fourier transform infrared spectroscopy (FTIR) outcomes explain distinctive peaks not affected other components displayed same functional group's band very slight shifting. This indicates there no interaction between components. Therefore, these excipients found be compatible felodipine. In conclusion, efficient method enhance permeatioins drugs have poor water (lipophilic drugs).