Formulation and Characterization Liposome of Oxcarbazepine

Oxcarbazepine (OXC) was used as first line therapy or additional for treatment of partialand secondary seizures. The penetration OXC into nasal mucosa can be enhanced by formingliposome. This research has the aim to prepare and characterize iposome laoding OXC. OXCliposome formula composed using soya lechitin cholesterol with various amount usingthin film hydration method. Characterization determining encapsulation efficiency (%EE), pH,viscosity, particle size, polydispersity index, zeta potential, in vitro release. liposome ofOXC also analyzed its stability based on heating-coling cycle proportion bestformula obtained at 42,11 mg yield %EE 92,63%, pH 8,47,viscosity 1,10 cP, decreased test 0,34%. results particlediameter were 579 nm, index (PDI) 0,34, potential -99,38 mV. vitrorelease studied compared result releaseliposome (F2) ahowed increase (62,26%) than (41,97%).