منابع مشابه
Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules
A number of cellular processes use both microtubules and actin filaments, but the molecular machinery linking these two cytoskeletal elements remains to be elucidated in detail. Formins are actin-binding proteins that have multiple effects on actin dynamics, and one formin, mDia2, has been shown to bind and stabilize microtubules through its formin homology 2 (FH2) domain. Here we show that thr...
متن کاملSnapShot: Formins
See online version for legend and references. Autosomal-dominant nonsyndromic deafness (DFNA1), myeloproliferative defects, defects in T lymphocyte traffi cking and proliferation, tumor cell invasion, defects in natural killer lymphocyte function DIAPH2 (mDia3) Cdc42 Kinetochore Stable microtubule attachment to kinetochore for chromosome alignment Premature ovarian failure DIAPH3 (mDia2) Increa...
متن کاملDissecting the involvement of formins in Bud6p-mediated cortical capture of microtubules in S. cerevisiae.
In S. cerevisiae, spindle orientation is linked to the inheritance of the ;old' spindle pole by the bud. A player in this asymmetric commitment, Bud6p, promotes cortical capture of astral microtubules. Additionally, Bud6p stimulates actin cable formation though the formin Bni1p. A relationship with the second formin, Bnr1p, is unclear. Another player is Kar9p, a protein that guides microtubules...
متن کاملFormins at a glance.
Formins are conserved actin polymerization machines that have instrumental roles in controlling rearrangements of the actin cytoskeleton and have recently been shown to directly regulate microtubule dynamics. Here, and on the accompanying poster, we aim to organize a rapidly expanding body of literature on this diverse protein family, summarizing the common properties that apply to most formins...
متن کاملDynamic Simulation and Mechanical Properties of Microtubules
This work is conducted to obtain mechanical properties of microtubule. For this aim, interaction energy in alpha-beta, beta-alpha, alpha-alpha, and beta-beta dimers was calculated using the molecular dynamic simulation. Force-distance diagrams for these dimers were obtained using the relation between potential energy and force. Afterwards, instead of each tubulin, one sphere with 55 KDa weight ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2010
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2009.07.006