Formation and Evolution of Nanoscale Calcium Phosphate Precursors under Biomimetic Conditions

نویسندگان

چکیده

Simulated body fluids (SBFs) that mimic human blood plasma are widely used media for in vitro studies an extensive array of research fields, from biomineralization to surface and corrosion sciences. We show these solutions undergo dynamic nanoscopic conformational rearrangements on the timescale minutes hours, even though they commonly considered stable or metastable. In particular, we find characterize nanoscale inhomogeneities made calcium phosphate (CaP) aggregates emerge homogeneous SBFs within a few hours evolve into prenucleation species (PNS) act as precursors CaP crystallization processes. These ionic clusters consist ?2 nm large spherical building units can aggregate suprastructures with sizes over 200 nm. residence times ions PNS depend critically total surface. findings particularly relevant understanding nonclassical phenomena, which assumed blocks final crystal structure.

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ژورنال

عنوان ژورنال: Analytical Chemistry

سال: 2021

ISSN: ['1520-6882', '0003-2700']

DOI: https://doi.org/10.1021/acs.analchem.1c01561