Formaldehyde fixation.

The use of formaldehyde as a biological reagent occurred rather late in the history of histological methodology. The reason for this lay not in any lack of astuteness on the part of pathologists and histologists, but rather with the late development of formaldehyde manufacture by the chemical industry. While formaldehyde was discovered by Butlerov in 1859, practical aspects of the manufacture o...

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Effects of formaldehyde fixation on basilar artery caliber.

The external diameters of rat and rabbit basilar arteries were determined before and after formaldehyde fixation in relaxed and drug constricted vessels. Fixation usually resulted in an immediate vessel constriction followed by partial relaxation after several hours. However, the results were inconstant from vessel to vessel and from area to area of the same vessel. It is concluded that morphol...

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Brief Communication Effects of Formaldehyde Fixation on Basilar Artery Caliber

The external diameters of rat and rabbit basilar arteries were determined before and after formaldehyde fixation in relaxed and drug constricted vessels. Fixation usually resulted in an immediate vessel constriction followed by partial relaxation after several hours. However, the results were inconstant from vessel to vessel and from area to area of the same vessel. It is concluded that morphol...

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A Temporal Threshold for Formaldehyde Crosslinking and Fixation

BACKGROUND Formaldehyde crosslinking is in widespread use as a biological fixative for microscopy and molecular biology. An assumption behind its use is that most biologically meaningful interactions are preserved by crosslinking, but the minimum length of time required for an interaction to become fixed has not been determined. METHODOLOGY Using a unique series of mutations in the DNA bindin...

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Brief Communication Effects of Formaldehyde Fixation on Basilar Artery Caliber

The external diameters of rat and rabbit basilar arteries were determined before and after formaldehyde fixation in relaxed and drug constricted vessels. Fixation usually resulted in an immediate vessel constriction followed by partial relaxation after several hours. However, the results were inconstant from vessel to vessel and from area to area of the same vessel. It is concluded that morphol...

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Formaldehyde fixation.

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