Formal Anti‐Markovnikov Addition of Water to Olefins by Titanocene‐Catalyzed Epoxide Hydrosilylation: From Stoichiometric to Sustainable Catalytic Reactions

Here, the evolution of titanocene-catalyzed hydrosilylation epoxides that yields corresponding anti-Markovnikov alcohols is summarized. The study focuses on aspects sustainability, efficient catalyst activation, and stereoselectivity. latest variant reaction employs polymethylhydrosiloxane (PMHS), a waste product Müller–Rochow process as terminal reductant, features an activation with benzylMgBr use bench stable Cp2TiCl2 precatalyst. combination olefin epoxidation epoxide provides uniquely approach to formal addition H2O olefins.