منابع مشابه
Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac.
Chimaerins are the only known RhoGAPs (Rho GTPase-activating proteins) that bind phorbol ester tumour promoters and the lipid second messenger DAG (diacylglycerol), and show specific GAP activity towards the small GTPase Rac. This review summarizes our knowledge of the structure, biochemical and biological properties of chimaerins. Recent findings have established that chimaerins are regulated ...
متن کاملRac in the Act of Forgetting
Forgetting has been thought to occur as a result of the natural decay of the neuronal changes induced by learning or because of interference from other cognitive functions. In this issue, Shuai et al. (2010) find that the small G protein Rac may function as a switch for remembering versus forgetting.
متن کاملThe small G-protein Rac mediates depolarization-induced superoxide formation in human endothelial cells.
Superoxide anions impair nitric oxide-mediated responses and are involved in the development of hypertensive vascular hypertrophy. The regulation of their production in the vascular system is, however, poorly understood. We investigated whether changes in membrane potential that occur in hypertensive vessels modulate endothelial superoxide production. In cultured human umbilical vein endothelia...
متن کاملForgetting Is Regulated through Rac Activity in Drosophila
Initially acquired memory dissipates rapidly if not consolidated. Such memory decay is thought to result either from the inherently labile nature of newly acquired memories or from interference by subsequently attained information. Here we report that a small G protein Rac-dependent forgetting mechanism contributes to both passive memory decay and interference-induced forgetting in Drosophila. ...
متن کاملSmall G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo
Glioblastoma is the most common and aggressive malignant brain tumor in adults. The existence of glioblastoma stem cells (GSCs) or stem-like cells (stemloids) may account for its invasiveness and high recurrence. Rac proteins belong to the Rho small GTPase subfamily which regulates cell movement, proliferation, and survival. To investigate whether Rac proteins can serve as therapeutic targets f...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2010
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-010-0077-z