Foreword: Christy and France

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Foreword and Dedication

SIADH and hyponatraemia: foreword

Hyponatraemia is common, affecting about one in five of all hospitalized patients. Minor degrees of chronic hyponatraemia cause cognitive and motor impairment, and severe hyponatraemia is associated with substantial morbidity and mortality. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatraemia and is often poorly understood and inappropriately treat...

Editorial Foreword

Evidence is steadily accumulating that a large number of diseases in which historical therapies have made no signifi cant impact in outcome are suddenly for the fi rst time effectively treated to yield outcomes unimaginable with prior therapies. Because of the complexities of signaling mechanisms and variation in these mechanisms between disease processes, thorough and standardized testing of e...