Food preservative sorbic acid deregulates hepatic fatty acid metabolism

Fatty acid metabolism and hepatic lipogenesis.

The conversion of octanoate-l-Cl4 to radioacetoacetate and the effect of pyruvate on this process are dependent on the K+ concentration in the incubation medium (1). These results prompted this investigation in which the incorporation of octanoate-l-Cl4 into fatty acids and cholesterol was determined in the presence of non-radioactive additions of pyruvate, succinate, and fumarate. Malonate was...

The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro.

Dysregulation of hepatic fatty acid metabolism in chronic kidney disease.

BACKGROUND Chronic kidney disease (CKD) results in hypertriglyceridemia which is largely due to impaired clearance of triglyceride-rich lipoproteins occasioned by downregulation of lipoprotein lipase and very low-density lipoprotein (LDL) receptor in the skeletal muscle and adipose tissue and of hepatic lipase and LDL receptor-related protein in the liver. However, data on the effect of CKD on ...

Sorbic Acid as a Wine Preservative-Its Efficacy and Organoleptic Threshold

Sorbic acid was added to wines in different concentrations to determine its effect on the inhibition of yeasts in semi sweet wines. Sorbic acid proved to be an effective inhibitor of yeast growth when used at a concentration of 200 mgle in conjunction with a concentration of 100 mg S02IC. As the sorbic acid does not kill the yeast cells but only inhibits them it is imperative that the wine shou...

Impaired Fatty Acid Metabolism

To establish whether insulin resistance and/or postprandial fatty acid metabolism might contribute to familial combined hyperlipidemia (FCH) we have examined parameters of insulin resistance and lipid metabolism in six FCH kindreds. Probands and relatives (n = 56) were divided into three tertiles on the basis of fasting plasma triglycerides (TG). Individuals in the highest tertile (TG > 2.5 mM;...