Food Craving in Obese Subjects: Its Correlation with Atherogenic Index and Feeding Behavior-Related Gene Expression

Obesity is influenced by environmental, behavioral, and genetic factors; particularly genes related to the regulation of lipids addictive behavior. Food craving (FC) a physiological behavioral response that triggers intense desire ingest food, food with high energy, fat, and/or sweet content. Objective: To evaluate relationship between prevalence FC in obese subjects blood as well determine transcriptional modulation CART, DRD2, FTO. Method: Transverse, comparative, randomized study including 21 participants (BMI, ≥30 kg/m2] 20 normal weight ≤25 kg/m2). We determined FTO expressions; evaluated lipid levels; obtained trait scores on Craving Questionnaire-Trait, multifactorial instrument validated for Mexican population. Results: The DRD2 expression was significantly increased (p = 0.027) CART decreased 0.001) compared participants. did not show significant differences. Questionnaire-Trait showed ≥72 Conclusions: Linear regression model analysis predictor atherogenic index (ATH), independently BMI, gene DRD2.