Fondaparinux-Associated Heparin-Induced Thrombocytopenia
نویسندگان
چکیده
منابع مشابه
Fondaparinux-associated heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) is an immune-mediated clinical syndrome of thrombocytopenia and thrombosis occurring after exposure to heparin. HIT most commonly occurs after exposure to unfractionated heparin but has also been reported with low-molecular-weight heparin. To date, there have been very few reports of HIT with the pentasaccharide fondaparinux, and some have proposed fondapa...
متن کاملThe serological profile of fondaparinux-associated heparin-induced thrombocytopenia syndrome.
doi:10.1160/TH12-03-0201 Thromb Haemost 2012; 108: 394–396 Dear Sirs, Heparin-induced thrombocytopenia (HIT) is a prothrombotic adverse drug effect caused by platelet-activating antibodies that recognise multimolecular complexes of platelet factor 4 (PF4) bound to heparin (1, 2). HIT is almost invariably triggered by proximate treatment with unfractionated heparin (UFH) or low-molecular-weight ...
متن کاملThe Fondaparinux Paradox: Fondaparinux-Related Heparin-induced Thrombocytopenia
Fondaparinux, a pentasaccharide administered for heparin-induced thrombocytopenia (HIT), can lead to the occurrence of thrombocytopenia. This patient underwent aortic stent graft placement for Salmonella paratyphi A-infected abdominal aortic aneurysm. Fondaparinux was administered for anticoagulation that led to a dramatic decline in his platelet counts. Investigations revealed HIT profile, PF4...
متن کاملHeparin induced thrombocytopenia
Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
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A 45-year-old female presented with complaints of left leg cramps lasting 2 weeks and 1 day of leg swelling. Doppler ultrasound revealed left lower extremity deep vein thrombosis (DVT), which was thought to be secondary to trauma. The patient had a history of ampullary cancer that had metastasized to the liver, for which she underwent a Whipple procedure, radiotherapy, and chemotherapy. Additio...
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ژورنال
عنوان ژورنال: Baylor University Medical Center Proceedings
سال: 2012
ISSN: 0899-8280,1525-3252
DOI: 10.1080/08998280.2012.11928771