Fomepizole in the treatment of ethylene glycol poisoning
نویسندگان
چکیده
منابع مشابه
Fomepizole for ethylene glycol and methanol poisoning.
n engl j med 360;21 nejm.org may 21, 2009 2216 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented...
متن کاملTreatment of patients with ethylene glycol or methanol poisoning: focus on fomepizole
Ethylene glycol (EG) and methanol are responsible for life-threatening poisonings. Fomepizole, a potent alcohol dehydrogenase (ADH) inhibitor, is an efficient and safe antidote that prevents or reduces toxic EG and methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, ba...
متن کاملThe Role of Hemodialysis and Fomepizole in Ethylene Glycol Intoxication
Ethylene glycol is one of the most common toxic alcohol ingestions requiring hemodialysis for treatment. With the FDA approval in 1997 of fomepizole (4-methylpyrazole), the indications for hemodialysis in addition to fomepizole for ethylene glycol poisoning have been examined in recent articles and case reports. Fomepizole, a competitive inhibitor of alcohol dehydrogenase, binds to the same sit...
متن کاملRole of fomepizole in the management of ethylene glycol toxicity.
OBJECTIVE To systematically review English-language articles on fomepizole administration in patients with ethylene glycol poisoning. DATA SOURCES MEDLINE, EMBASE, Current Contents, and PubMed. Search terms were fomepizole, 4-methylpyrazole, and ethylene glycol. The search was supplemented with a bibliographic review of all relevant articles. STUDY SELECTION All published reports of fomepiz...
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ژورنال
عنوان ژورنال: CJEM
سال: 2002
ISSN: 1481-8035,1481-8043
DOI: 10.1017/s1481803500006382