Following the mevalonate pathway to bone heal alley
نویسندگان
چکیده
منابع مشابه
Discovery of a metabolic alternative to the classical mevalonate pathway
Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes. The search for these missing elements led to the discovery of isopentenyl phosphate kinase (IPK), one of two activities necessary to furnish the universal five-carbon is...
متن کاملExploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma.
Statin inhibitors, used to control hypercholesterolemia, trigger apoptosis of hematologic tumor cells and therefore have immediate potential as anticancer agents. Evaluations of statins in acute myelogenous leukemia and multiple myeloma have shown that statin efficacy is mixed, with only a subset of tumor cells being highly responsive. Our goal was to distinguish molecular features of statin-se...
متن کاملThe mevalonate pathway of Staphylococcus aureus.
Isoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophosphate is absolutely required for the formation of cell wall peptidoglycan and other cell surface str...
متن کاملMevalonate Pathway: Role of Bisphosphonates and Statins
Aminobisphosphonates and statins act in the same metabolic way. Bisphosphonates are considered the drugs of choice for the treatment of osteoporosis, like statins for the treatment of atherosclerosis. Aminobisphosphonates inhibit cholesterol biosynthesis and this might be relevant for their actions on atherosclerosis too. Recently, HMG-CoA reductase inhibitors (statins), have been correlated to...
متن کاملThe mevalonate pathway regulates primitive streak formation via protein farnesylation
The primitive streak in peri-implantation embryos forms the mesoderm and endoderm and controls cell differentiation. The metabolic cues regulating primitive streak formation remain largely unknown. Here we utilised a mouse embryonic stem (ES) cell differentiation system and a library of well-characterised drugs to identify these metabolic factors. We found that statins, which inhibit the mevalo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Orthopaedica
سال: 2007
ISSN: 1745-3674,1745-3682
DOI: 10.1080/17453670710046549