Folding of the Pit1 homeodomain near the speed limit
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چکیده
منابع مشابه
Folding of the Pit1 homeodomain near the speed limit.
Current questions in protein folding mechanisms include how fast can a protein fold and are there energy barriers for the folding and unfolding of ultrafast folding proteins? The small 3-helical engrailed homeodomain protein folds in 1.7 μs to form a well-characterized intermediate, which rearranges in 17 μs to native structure. We found that the homologous pituitary-specific transcription fact...
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15 صفحه اولA speed limit for protein folding.
Recent observations of fast steps in protein folding (1-3) address the following question: what is the shortest time that would be required for folding? The paper by Hagen et al. (4) in this issue of the Proceedings provides strong experimental support for a speed limit that is governed by diffusion. Diffusion is known to limit the rates of many of the activities of proteins, including enzymati...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1017832108