Folate receptor targeting silica nanoparticle probe for two-photon fluorescence bioimaging
نویسندگان
چکیده
منابع مشابه
Folate receptor targeting silica nanoparticle probe for two-photon fluorescence bioimaging
Narrow dispersity organically modified silica nanoparticles (SiNPs), diameter ~30 nm, entrapping a hydrophobic two-photon absorbing fluorenyl dye, were synthesized by hydrolysis of triethoxyvinylsilane and (3-aminopropyl)triethoxysilane in the nonpolar core of Aerosol-OT micelles. The surface of the SiNPs were functionalized with folic acid, to specifically deliver the probe to folate receptor ...
متن کاملHigh-Fidelity Hydrophilic Probe for Two-Photon Fluorescence Lysosomal Imaging
The synthesis and characterization of a novel two-photon-absorbing fluorene derivative, LT1, selective for the lysosomes of HCT 116 cancer cells, is reported. Linear and nonlinear photophysical and photochemical properties of the probe were investigated to evaluate the potential of the probe for two-photon fluorescence microscopy (2PFM) lysosomal imaging. The cytotoxicity of the probe was inves...
متن کاملBipolar and fixable probe targeting mitochondria to trace local depolarization via two-photon fluorescence lifetime imaging.
Polarization/depolarization levels of different single mitochondria in a cell are inhomogeneous, and always varying. Because depolarization is an indicator of mitochondrial dysfunction, tracing local depolarization is highly desirable. The existing fluorescent probes, however, are not well suited for this task, although they are applicable to assess the average polarization extents of whole cel...
متن کاملFluorescent silica nanoparticle-based probe for the detection of ozone via fluorescence resonance energy transfer.
A fluorescence resonance energy transfer (FRET) platform for the detection of ozone was developed by combining the overlap of the fluorescence spectrum of Ru(bpy)3(2+)-doped silica nanoparticles with the absorption spectrum of indigo carmine at around 600 nm. This FRET system can be used to detect ozone simply within 10 min. Simple qualitative ozone detection methods using cotton swabs or paper...
متن کاملA folate receptor-specific activatable probe for near-infrared fluorescence imaging of ovarian cancer.
We have developed a folate receptor-specific activatable probe for in vivo near-infrared fluorescence imaging of ovarian cancer. This probe becomes highly fluorescent only when its linker is cleaved by a tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomedical Optics Express
سال: 2010
ISSN: 2156-7085
DOI: 10.1364/boe.1.000453