Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro
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چکیده
منابع مشابه
Antibody-mediated specific binding and cytotoxicity of liposome-entrapped doxorubicin to lung cancer cells in vitro.
Liposome entrapment of doxorubicin has been shown to reduce its cardiotoxicity in vivo and increase its therapeutic index. A further improvement in therapeutic index could be achieved through targeting of liposome-entrapped drug selectively to cancer cells. Monoclonal antibodies against the squamous lung cancer cell line KLN-205 have been ligated to the surface of long-circulating (Stealth) and...
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Liposome entrapment of doxorubicin has been shown to reduce its cardiotoxicity in vivo and increase its therapeutic index. A further im provement in therapeutic index could be achieved through targeting of liposome-entrapped drug selectively to cancer cells. Monoclonal anti bodies against the squamous lung cancer cell line KI N 205 have been ligated to the surface of long-circulating (Stealth) ...
متن کاملTargeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome.
Liposomal drugs accumulate only in perivascular regions in tumors after i.v. injection. Thus, they cannot kill tumor cells in deeper tissue layers. To circumvent this problem, we investigated effects of doxorubicin (DOX) encapsulated in a lysolecithin-containing thermosensitive liposome (LTSL) on tumor microcirculation because damaging microvessels would stop nutrient supply to deeper tumor cel...
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BACKGROUND Luminescent nanobioprobes with cell-targeting specificity are likely to find important applications in bioanalysis, biomedicine, and clinical diagnosis. Quantum dots (QDs) are unique and promising materials for such a purpose because of their fluorescence and large surface area for attaching cell-targeting molecules. METHODS We produced water-dispersible QDs by coating hydrophobic ...
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Anti-tumor effect of Doxorubicin with Bubble Liposome and Ultrasound Yoshinori Ueno1, Syozo Sonoda2, Ryo Suzuki3, Masahiro Yokouchi1, Yasuomi Kawasoe1, Kazuo Maruyama3, Taiji Sakamoto2, Setsuro Komiya1 1Department of Orthopaedic Surgery, kagoshima Graduate School of Medicine and Dental Sciences, Kagoshima, Japan; 2Department of Ophthalmology, kagoshima Graduate School of Medicine and Dental Sci...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 1995
ISSN: 0005-2736
DOI: 10.1016/0005-2736(94)00235-h