Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery

Enhanced brain delivery of lamotrigine with Pluronic® P123-based nanocarrier

BACKGROUND P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. However, their applications in the delivery of AEDs have not been adequately investigated. The objective...

Synthesis and Characterization of Dual-Sensitive Fluorescent Nanogels for Enhancing Drug Delivery and Tracking Intracellular Drug Delivery

Here, dual-sensitive fluorescent branched alginate-polyethyleneimine copolymer (bAPSC) nanogels were synthesized from thiolated alginate and stearoyl-derivatized branched polyethyleneimine. The formation of bAPSC conjugates was confirmed through proton nuclear magnetic resonance and Fourier transform infrared spectroscopy, whereas dynamic light scattering was used to measure the particle size a...

Dual responsive supramolecular nanogels for intracellular drug delivery.

Supramolecular nanogels cross-linked by host-guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of can...

Folate-conjugated nanodiamond for tumor-targeted drug delivery

Tumor-targeted drug delivery by folate conjugated amphiphiles

Drug delivery by folate conjugated amphiphiles Abstract A series of amphiphilic conjugates of folic acid and aliphatic fatty acids was designed to serve as targeted drug delivery carriers for anticancer agents. The effectiveness of targeted delivery of amphiphile was evaluated using folate receptor positive HeLa cells and Caco-2 cells that do not express folate receptor. Wild type HeLa cells we...