Folate and Borneol Modified Bifunctional Nanoparticles for Enhanced Oral Absorption

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake

Docetaxel is a potent anticancer drug, but development of an oral formulation has been hindered mainly due to its poor oral bioavailability. In this study, solid lipid nanoparticles (SLNs) surface-modified by Tween 80 or D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS 1000) were prepared and evaluated in terms of their feasibility as oral delivery systems for docetaxel. Tween 80-e...

متن کامل

Folate-modified lipid–polymer hybrid nanoparticles for targeted paclitaxel delivery

The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled, and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of 1) a poly(ε-caprolactone) hydrophobic core based on self-assembly of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolact...

متن کامل

Design of lipid modified polymeric nanoparticles for improvement of oral absorption of insulin

In this study, lipid modified polymeric nanoparticles for oral delivery of insulin was developed. Firstly, chitosan nanoparticles (CS NPs) was prepared by cross-linking of chitosan with triphosphate TPP as the core of the core-shell structured nanocarriers. Then lipid coating chitosan nanoparticles (LCS) was prepared by co-incubation of the CS NPs with EPC liposomes. The morphologies of these n...

متن کامل

Folate absorption

Folic acid, or pteroylglutamic acid, is the parent substance of a large group of related compounds called 'folates'. All folate compounds have the same basic molecular structure consisting of three parts: pteridine, para-aminobenzoate (these two together forming a pteroyl group), and L-glutamic acid (Fig. 1). Pteroylglutamic acid itself is a stable, watersoluble compound with a molecular weight...

متن کامل

Mechanism of enhanced oral absorption of hydrophilic drug incorporated in hydrophobic nanoparticles

Hydroxysafflor yellow A (HSYA) is an effective ingredient of the Chinese herb Carthamus tinctorius L, which has high water solubility and low oral bioavailability. This research aims to develop a hydrophobic nanoparticle that can enhance the oral absorption of HSYA. Transmission electron microscopy and freeze-fracture replication transmission election microscopy showed that the HSYA nanoparticl...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Pharmaceutics

سال: 2018

ISSN: 1999-4923

DOI: 10.3390/pharmaceutics10030146