Focal Gastric Mucosal Blood Flow in Aspirin-induced Ulceration
نویسندگان
چکیده
منابع مشابه
Acute gastric ulceration in rats with obstructive jaundice with special reference to gastric mucosal blood flow.
The mechanism of acute gastric ulceration in rats with obstructive jaundice was investigated in terms of the changes in the gastric mucosal blood flow, and the effect of vagotomy on ulceration was examined. 188 Sprague-Dawley rats weighing about 250 g were prepared and divided into 4 groups as follows; control group (sham operation), jaundiced group (ligation of the bile duct), vagotomized grou...
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The eflect of orally administered prostaglandin 15(R)15 methyl-E2 methyl ester on aspirin and taurocholic acid-induced gastric mucosal haemorrhage has been studied in rats. The incidence of haemorrhage induced by aspirin (26-7 mM), 64 mg/kg, together with taurocholic acid (2.5 mM), was significantly reduced from 53l6% to 19l5% by the addition of the prostaglandin (9-9 ,uM), P < 0 01. The incide...
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Salivary nitrate from dietary or endogenous sources is reduced to nitrite by oral bacteria. In the acidic stomach, nitrite is further reduced to bioactive nitrogen oxides, including nitric oxide (NO). In this study, we investigated the gastroprotective role of nitrate intake and of luminally applied nitrite against provocation with diclofenac and taurocholate. Mucosal permeability ((51)Cr-EDTA ...
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Gastric mucosa exhibits the ability to adapt to ulcerogenic action of aspirin but the mechanism of this phenomenon is unknown. In this study, acute gastric lesions were produced by single or repeated doses of acidified aspirin in rats with intact or resected salivary glands and with intact or suppressed synthase of nitric oxide. A single oral dose of aspirin produced a dose dependent increase i...
متن کاملprevention by cortisone of aspirin -induced gastric ulceration in the rat
the effect of cortisone on the experimental gastric ulceration produced by intraperitoneal injection of aspirin in the rat is studied. cortisone has significantly prevented the appearance of aspirin_ induced gastric ulceration. the possible mechanism of this effect of cortisone is discussed.
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 1987
ISSN: 0003-4932
DOI: 10.1097/00000658-198704000-00010