FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein
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چکیده
منابع مشابه
FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein
Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Abeta) accumulation, which is associated with Alzheimer disease, results in synaptic loss and impaired neurotransmission. Fragile X mental retardation protein (FMRP) is a cytoplasmic mRNA binding protein whose expression is lost in fragile X syndrome. Here we show that FMRP binds to the co...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2007
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0050052