Fluoroquinolone Use andClostridium difficile–associated Diarrhea
نویسندگان
چکیده
منابع مشابه
Fluoroquinolone Use and Clostridium difficile–Associated Diarrhea
We performed a case-control study to evaluate the association between antibiotic use and Clostridium difficile-associated diarrhea (CDAD), matching for admission unit and time at risk for CDAD. A multivariable regression model showed that treatment with fluoroquinolones (odds ratio 12.7; 95% confidence interval 2.6 to 61.6) was the strongest risk factor for CDAD.
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Fluoroquinolones are an important class of antibiotics that are widely used in adult patients because of their broad spectrum of activity, good tissue penetration, and oral bioavailability. However, fluoroquinolone use in children is limited because juvenile animals developed arthropathy in previous experiments on fluoroquinolone use. Indications for fluoroquinolone use in patients younger than...
متن کاملPseudomonas aeruginosa, Staphylococcus aureus, and Fluoroquinolone Use
Few long-term multicenter investigations have evaluated the relationships between aggregate antimicrobial drug use in hospitals and bacterial resistance. We measured fluoroquinolone use from 1999 through 2003 in a network of US hospitals. The percentages of fluoroquinolone-resistant Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) were obtained from yearly antibiogr...
متن کاملInvestigating the fluoroquinolone-topoisomerase interaction by use of novel fluoroquinolone and quinazoline analogs
Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 3 INVESTIGATING THE FLUOROQUINOLONE-TOPOISOMERASE INTERACTION BY USE OF NOVEL FLUOROQUINOLONE AND QUINAZOLINE ANALOGS by Kevin Randall Marks A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy ...
متن کاملTopical fluoroquinolone use as a risk factor for in vitro fluoroquinolone resistance in ocular cultures.
OBJECTIVE To determine whether recent use of topical fluoroquinolones is a risk factor for in vitro fluoroquinolone resistance in Staphylococcus aureus ocular isolates. METHODS Disk diffusion susceptibility testing for ciprofloxacin, moxifloxacin, and gatifloxacin was performed for all ocular isolates of S aureus at the Francis I. Proctor Foundation microbiology laboratory from January 1, 200...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2003
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid0906.020385