Fluorine-containing nanoemulsions for MRI cell tracking

Fluorine-19 MRI Contrast Agents for Cell Tracking and Lung Imaging

Fluorine-19 ((19)F)-based contrast agents for magnetic resonance imaging stand to revolutionize imaging-based research and clinical trials in several fields of medical intervention. First, their use in characterizing in vivo cell behavior may help bring cellular therapy closer to clinical acceptance. Second, their use in lung imaging provides novel noninvasive interrogation of the ventilated ai...

Tracking the Fate of Stem Cell Implants with Fluorine-19 MRI

BACKGROUND In this study we used cellular magnetic resonance imaging (MRI) to detect mesenchymal stem cells (MSC) labeled with a Fluorine-19 (19F) agent. 19F-MRI offers unambiguous detection and in vivo quantification of labeled cells. METHODS We investigated two common stem cell transplant mouse models: an immune competent, syngeneic transplant model and an immune compromised, xenograft tran...

Fluorine-containing Elastomers Introduction

Optimization of perfluorocarbon nanoemulsions for molecular imaging by 19F MRI

Introduction of fluorine and fluorine-containing functional groups.

Over the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis. The most challenging transformation remains the formation of the parent C-F bond, primarily as a consequence of the high hydration energy of fluoride, strong metal-fluorine bonds, and highly polarized bonds to fluorine. Most fluori...