Fluorination of Inorganic Sulfur Compounds

Symposium on metabolism of inorganic compounds. V. Comparative metabolism of inorganic sulfur compounds in microorganisms.

Chemo-enzymatic fluorination of unactivated organic compounds.

Fluorination has gained an increasingly important role in drug discovery and development. Here we describe a versatile strategy that combines cytochrome P450-catalyzed oxygenation with deoxofluorination to achieve mono- and polyfluorination of nonreactive sites in a variety of organic scaffolds. This procedure was applied for the rapid identification of fluorinated drug derivatives with enhance...

Subsystem: Inorganic sulfur (sulfate) assimilation

Introduction Sulfur is required for the biosynthesis of several essential compounds like amino acids (cysteine and methionine), vitamins (biotin, thiamin), and prosthetic groups (Fe-S clusters) in all organisms. In order to synthesize these compounds, the sulfur has usually to be in a reduced state, most commonly as (hydrogen) sulfide. In the absence of an environmental supply of reduced sulfur...

Oxidation of reduced inorganic sulfur compounds by bacteria: emergence of a common mechanism?

Regulation of a novel Acidithiobacillus caldus gene cluster involved in metabolism of reduced inorganic sulfur compounds.

Acidithiobacillus caldus has been proposed to play a role in the oxidation of reduced inorganic sulfur compounds (RISCs) produced in industrial biomining of sulfidic minerals. Here, we describe the regulation of a new cluster containing the gene encoding tetrathionate hydrolase (tetH), a key enzyme in the RISC metabolism of this bacterium. The cluster contains five cotranscribed genes, ISac1, r...