Fluid‐based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative diseases
نویسندگان
چکیده
منابع مشابه
Pathologies of Axonal Transport in Neurodegenerative Diseases.
Gene products such as organelles, proteins and RNAs are actively transported to synaptic terminals for the remodeling of pre-existing neuronal connections and formation of new ones. Proteins described as molecular motors mediate this transport and utilize specialized cytoskeletal proteins that function as molecular tracks for the motor based transport of cargos. Molecular motors such as kinesin...
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Biomarkers for neurodegenerative diseases should reflect the central pathogenic processes of the diseases. The field of clinical proteomics is especially well suited for discovery of biomarkers in cerebrospinal fluid (CSF), which reflects the proteins in the brain under healthy conditions as well as in several neurodegenerative diseases. Known proteins involved in the pathology of neurodegenera...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2018
ISSN: 0022-3042,1471-4159
DOI: 10.1111/jnc.14594