Fluctuation in shear rate, with unaltered mean shear rate, improves brachial artery flow-mediated dilation in healthy, young men
نویسندگان
چکیده
منابع مشابه
Brachial Artery Flow-mediated Dilation Following Exercise with Augmented Oscillatory and Retrograde Shear Rate
BACKGROUND Acute doses of elevated retrograde shear rate (SR) appear to be detrimental to endothelial function in resting humans. However, retrograde shear increases during moderate intensity exercise which also enhances post-exercise endothelial function. Since SR patterns differ with the modality of exercise, it is important to determine if augmented retrograde SR during exercise influences p...
متن کاملImpact of controlling shear rate on flow-mediated dilation responses in the brachial artery of humans.
The reactive hyperemia test (RHtest) evokes a transient increase in shear stress as a stimulus for endothelial-dependent flow-mediated vasodilation (EDFMD). We developed a noninvasive method to create controlled elevations in brachial artery (BA) shear rate (SR, estimate of shear stress), controlled hyperemia test (CHtest), and assessed the impact of this vs. the RHtest approach on EDFMD. Eight...
متن کاملLocal Shear Stress and Brachial Artery Flow–Mediated Dilation
Endothelium-dependent flow-mediated dilation is a homeostatic response to short-term increases in local shear stress. Flow-mediated dilation of the brachial artery in response to postischemic reactive hyperemia is impaired in patients with cardiovascular disease risk factors and may reflect local endothelial dysfunction in the brachial artery. However, previous studies have largely neglected th...
متن کاملAssociation of Flow-mediated Dilation with Shear Rate in Patients and Healthy Volunteers
Introduction: Flow mediated-dilation (FMD) is a noninvasive test of endothelial function based on shear stressdependent nitric oxide secretion causing vasodilation. Normalization of FMD to shear stress was previously proposed. The aim of present study is an examination of relationship between shear rate and FMD in patients with hypertension and atherosclerosis in comparison with healthy volunte...
متن کاملAcute impact of retrograde shear rate on brachial and superficial femoral artery flow‐mediated dilation in humans
Retrograde shear rate (SR) in the brachial artery (BA) is associated with endothelial dysfunction; a precursor to atherosclerosis. The BA does not typically manifest clinical atherosclerosis, whereas the superficial femoral artery (SFA) is more prone to developing plaque. Examine whether the impact of incremental levels of retrograde SR differs between atherosclerosis-prone (i.e., SFA) and -res...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2019
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00009.2019