Flow Synthesis of Biologically-Relevant Compound Libraries

Chemoenzymatic Synthesis of Biologically Relevant Heterocycles

Synthesis of natural product-inspired compound libraries

An important aim in biology research is the elucidation of the role of proteins in complex, dynamic biological systems through the selective perturbation of their function. In contrast to genetic perturbations, chemical perturbations of protein function are conditional, acute, easily tuneable and reversible. [1] Furthermore, drug development still largely depends on the availability of bioactiv...

New processes for the synthesis of biologically relevant heterocycles*

This article describes the utility of certain readily accessible, ring-fused gem-dihalogenocyclopropanes as building blocks for the synthesis of heterocyclic and biologically active compounds.

Fluorous Mixture Synthesis (FMS) of Enantiomers, Diastereomers, and Compound Libraries.

Fluorous mixture synthesis (FMS) is a newly developed highly-efficient solution-phase technology. A set of substrates attached to homologous fluorous tags is mixed and taken through a sequence of organic reactions. The final mixtures are demixed by fluorous HPLC and detagged to give individually pure final products. Applications of FMS for the preparation of 2 enantiomers of pyridovericin, 16 d...

Biologically Relevant Multiple Sequence

BIOLOGICALLY RELEVANT MULTIPLE SEQUENCE ALIGNMENT Hyrum D. Carroll Department of Computer Science Doctor of Philosophy Researchers use multiple sequence alignment algorithms to detect conserved regions in genetic sequences and to identify drug docking sites for drug development. In this dissertation, a novel algorithm is presented for using physicochemical properties to increase the accuracy of...