Flow Estimation by Indicator Dilution (Bolus Injection)

Estimation of extravascular lung water by indicator-dilution techniques.

Cerebral blood flow measured by NMR indicator dilution in cats.

We developed techniques to assess the utility of a nuclear magnetic resonance (NMR) indicator for cerebral blood flow studies in cats, using Freon-22 for the first candidate. A PIN-diode-switched NMR experiment allowed the acquisition of an arterial as well as a cerebral fluorine-19 signal proportional to concentration vs. time in a 1.89 T magnet. Mean +/- SD blood:brain partition coefficients ...

Use of krypton85 for the measurement of cardiac output by the single-injection indicator-dilution technique.

W HEN radioactive krypton (Kr 85), a beta-emitting radioisotope, is introduced into the circulation, it does not act as a simple intravaseular indicator. As this substance, in solution in the blood stream, traverses the systemic capillary bed, it diffuses freely into the interstitial and intra-cellular spaces. When blood containing Kr 85 passes through the pulmonary capillary bed, approximately...

Estimation of absolute myocardial blood flow during first-pass MR perfusion imaging using a dual-bolus injection technique: comparison to single-bolus injection method.

PURPOSE To compare the dual-bolus to single-bolus quantitative first-pass magnetic resonance myocardial perfusion imaging for estimation of absolute myocardial blood flow (MBF). MATERIALS AND METHODS Dogs had local hyperemia of MBF in the left anterior descending (LAD) coronary artery (intracoronary adenosine). Animals (n = 6) had sequential single- and dual-bolus perfusion studies with micro...

The measurement of segmental venous flow by an indicator dilution method.

Several methods have been evolved for the measurement of venous flow in animals, but most have a limited application in man as they involve exposure of the appropriate blood vessel. These methods include the Ludwig type stromuhr (Tigerstedt, 1892), the thermostrontuhr (Rein, 1928; Schmidt and Walker, 1935; Shipley et al., 1942), the bubble flow meter (Soskin et al., 1934; Brunner, 1948), the di...