Floor plate develops upon depletion of tiggy-winkle and sonic hedgehog
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چکیده
منابع مشابه
Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling.
Sonic hedgehog signalling is essential for the embryonic development of many tissues including the central nervous system, where it controls the pattern of cellular differentiation. A genome-wide screen of neural progenitor cells to evaluate the Shh signalling-regulated transcriptome identified the forkhead transcription factor Foxj1. In both chick and mouse Foxj1 is expressed in the ventral mi...
متن کاملIntronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord.
The signalling molecule Sonic hedgehog (Shh) controls a wide range of differentiation processes during vertebrate development. Numerous studies have suggested that the absolute levels as well as correct spatial and temporal expression of shh are critical for its function. To investigate the regulation of shh expression, we have studied the mechanism controlling its spatial expression in the zeb...
متن کاملCombinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog.
Within the developing vertebrate nervous system, it is not known how progenitor cells interpret the positional information provided by inducing signals or how the domains in which distinct groups of neural cells differentiate are defined. Gli proteins may be involved in these processes. In the frog neural plate, we have previously shown that the zinc finger transcription factor Gli1 is expresse...
متن کاملInduction of motor neurons by Sonic hedgehog is independent of floor plate differentiation
BACKGROUND The differentiation of floor plate cells and motor neurons in the vertebrate neural tube appears to be induced by signals from the notochord. The secreted protein encoded by the Sonic hedgehog (Shh) gene is expressed by axial midline cells and can induce floor plate cells in vivo and in vitro. Motor neurons can also be induced in vitro by cells that synthesize Sonic hedgehog protein ...
متن کاملZebrafish wnt4b expression in the floor plate is altered in sonic hedgehog and gli-2 mutants
The floor plate of the neural tube serves an important function as a source of signals that pattern cell fates in the nervous system as well as directing proper axon pathfinding. We have cloned a novel zebrafish wnt family member, wnt4b, which is expressed exclusively in the floor plate. To place wnt4b in the context of known regulators of midline development, its expression was analyzed in the...
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ژورنال
عنوان ژورنال: genesis
سال: 2001
ISSN: 1526-954X,1526-968X
DOI: 10.1002/gene.1056