Flavonoids isolated from Tridax procumbens (TPF) inhibit osteoclasts differentiation and bone resorption
نویسندگان
چکیده
منابع مشابه
Resorption of bone by isolated rabbit osteoclasts.
A carborundum wheel was used to prepare slices of cortical bone that demonstrate a predictable surface appearance in the scanning electron microscope. Osteoclasts were mechanically disaggregated from neonatal rabbit long bones and settled onto these slices. After 24h in culture osteoclasts were associated with areas of excavation in the bone surface. These excavated areas typically showed a wel...
متن کاملBisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro.
Bisphosphonates are useful in treatment of disorders with increased osteoclastic activity, but the mechanism by which bisphosphonates act is unknown. We used cultures of chicken osteoclasts to address this issue, and found that 1-hydroxyethylidenediphosphonic acid (EHDP), dichloromethylidenediphosphonic acid (Cl2MDP), or 3-amino-1-hydroxypropylidene-1,1-diphosphonic acid (APD) all cause direct ...
متن کاملTwo new flavones from Tridax procumbens Linn.
Two new flavones, 8,3'-dihydroxy-3,7,4'-trimethoxy-6-O-β-D-glucopyranosyl flavone (1) and 6,8,3'-trihydroxy-3,7,4'-trimethoxyflavone (2) were isolated from Tridax procumbens Linn., together with the four known compounds puerarin (3), esculetin (4), oleanolic acid (5) and betulinic acid (6). The structures of the two new flavones were elucidated based on chemical analysis and spectral methods (I...
متن کاملAndrogens regulate bone resorption activity of isolated osteoclasts in vitro.
For many years it has been recognized that sex steroids have profound effects on bone metabolism. The current perception is that estrogen decreases bone resorption and androgen increases bone deposition. To investigate the potential for androgens to directly modulate bone resorption, we have examined avian osteoclast and human and mouse osteoclast-like cells for androgen responsiveness. There w...
متن کاملTridax Procumbens: a Medicinal Gift of Nature
INTRODUCTION Tridax procumbens, commonly known as coat buttons or tridax daisy, is a species of flowering plant in the daisy family. It is best known as a widespread weed and pest plant. It is native to the tropical Americas but it has been introduced to tropical, subtropical, and mild temperate regions worldwide. Traditionally, Tridax procumbens has been in use in India for wound healing, as A...
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ژورنال
عنوان ژورنال: Biological Research
سال: 2015
ISSN: 0717-6287
DOI: 10.1186/s40659-015-0043-6