Flavonoids fractions of Adansonia digitata L. fruits protects adult Wistar rats from mercury chloride-induced hepatorenal toxicity: histopathological and biochemical studies

Mercury chloride is a common heavy metal found in the environment, and it endangers both environment living organisms. The study aimed to show whether Flavonoids Fractions of Adansonia digitata (FAD) could protect rats from HgCl2-induced hepatorena toxicity. Thirty (30) were randomly assigned one six groups. first group was given no HgCl2 as control, while second single daily dose (0.5 mg/kg). treatment groups (III, IV, V) received mg/kg) along with 25 mg/kg, 50 75 mg/kg FAD, respectively. Group VI, Ascorbic Acid (200 standard control. After administration, blood serum experimental used for biochemical analysis. liver kidney organs obtained histological examination. AST, ALP, ALT, urea, creatinine, MDA levels all increased (group II), decreased SOD, CAT, GSH (p < 0.001), whereas FAD able prevent upsurge Urea, MDA. It also body. protected glomerulus degeneration prevented steatosis.