Flameless errekuntzak klima aldaketaren aurka

AURKA inhibition mimics BRCAness

SMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGFβ-independent manner.

UNLABELLED SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which is frequently overexpressed in cancer, increases the transcriptional activity of β-catenin/T-cell factor (TCF) complex by stabilizing β-catenin thr...

Die Evidenz der Klima- und Thalassotherapie. Ein Review

Von der Mitte des 19. bis in die Mitte des 20. Jahrhunderts hat die Klimatherapie z.B. in der Schweiz eine große Rolle bei Lungenund Knochentuberkulose gespielt. In etwa zeitgleich entstand die Thalassotherapie an der französischen Atlantikküste und in Deutschland im ersten Seebad Heiligendamm. Damals lagen zahlreiche Anwendungsbeobachtungen über gute Effekte der Klimatherapie vor. Ab der zweit...

Numerical calculation of the recirculation factor in flameless furnaces

This paper performs calculations of the recirculation factor in simulations of a flameless combustion furnace with different percentages of oxygen in air (from 21% to 100% O2). Results are compared with Magnussen’s recirculation theory and show that when there are chemical reactions, the recirculation results are overpredicted. An alternative correlation to Magnussen’s theory is proposed, usefu...

HDM2 regulation by AURKA promotes cell survival in gastric cancer.

PURPOSE Suppression of P53 (tumor protein 53) transcriptional function mediates poor therapeutic response in patients with cancer. Aurora kinase A (AURKA) and human double minute 2 (HDM2) are negative regulators of P53. Herein, we examined the role of AURKA in regulating HDM2 and its subsequent effects on P53 apoptotic function in gastric cancer. EXPERIMENTAL DESIGN Primary tumors and in vitr...