First return, then explore

On Explore-Then-Commit strategies

We study the problem of minimising regret in two-armed bandit problems with Gaussian rewards. Our objective is to use this simple setting to illustrate that strategies based on an exploration phase (up to a stopping time) followed by exploitation are necessarily suboptimal. The results hold regardless of whether or not the difference in means between the two arms is known. Besides the main mess...

First remodel, then recycle

M ultivesicular bodies (MVBs) are specialized endosomes that promote the degradation of membrane proteins by delivering them to lysosomes. This process is regulated by a series of endosomal sorting complexes required for transport (ESCRTs) (1). The ESCRT-0,-I, and-II complexes sequester ubiquitinated membrane proteins and recruit the ESCRT-III complex to drive the invagination and release of ca...

First Them, Then Us

First depressed, then discriminated against?

Each year a substantial share of the European population suffers from major depression. This mental illness may affect individuals' later life outcomes indirectly by the stigma it inflicts. The present study assesses hiring discrimination based on disclosed depression. To this end, between May 2015 and July 2015, we sent out 288 trios of job applications from fictitious candidates to real vacan...

Diet first, then medication for hypercholesterolemia.

REFERENCES 1. Yahalom J, Petrek JA, Biddinger PW, et al. Breast cancer in patients irradiated for Hodgkin's disease: a clinical and pathologic analysis of 45 events in 37 patients. et al. Long-term survival and competing causes of death in patients with early-stage Hodgkin's disease treated at age 50 or younger. Second malignancy after Hodgkin disease treated with radiation therapy with or with...