First-pass metabolism of cyclosporin by the gut
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Differentiation of gut and hepatic first pass metabolism and secretion of saquinavir in ported rabbits.
The current study was performed in intestinal and vascular access ported rabbits to quantify and differentiate the components of intestinal and hepatic first pass extraction (i.e., metabolism and secretion) of saquinavir (SQV) mediated by P-glycoprotein (P-gp) and CYP3A. SQV was administered i.v. (1-5 mg/kg) or into the upper small intestine (USI) (5 mg/kg). The roles of intestinal and hepatic ...
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Ranitidine increases the bioavailability of postprandial ethanol by the reduction of first pass metabolism.
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ژورنال
عنوان ژورنال: The Lancet
سال: 1991
ISSN: 0140-6736
DOI: 10.1016/0140-6736(91)92302-i