First manic/hypomanic episode in obsessive-compulsive disorder patients treated with antidepressants: A systematic review

High doses of antidepressants, particularly clomipramine and selective serotonin reuptake inhibitors (SSRIs), are the well-established treatment for obsessive-compulsive disorder (OCD), but manic/hypomanic episodes potential adverse events associated with this treatment. A systematic literature review was performed on in non-bipolar OCD patients. Clinical, sociodemographic antidepressant characteristics during switch were extracted using descriptive statistics. Data obtained from 20 case reports series. Switching mostly appeared first 12 weeks after initiation took place more frequently SSRI use (mostly fluoxetine) 64.3% cases. Clomipramine differed non-significantly between switching that beyond weeks. emerging before a lower defined daily dose antidepressants than These findings suggest there two independent involved OCD: a) they most (fluoxetine) regardless time it use, b) or had