Finding phenazine

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11,12-Dichloro­dibenzo[a,c]phenazine

The title compound, C20H10Cl2N2, has crystallographic twofold rotational symmetry [maximum deviation from the least-squares plane = 0.038 (1) Å]. In the crystal, weak π-π ring stacking inter-actions occur down the a-axis direction [minimum centroid-centroid separation = 3.7163 (8) Å].

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Phenazine biosynthesis by a pseudomonad.

The acidophilic bacterium Pseudomonas phenazinium (N.C.I.B. 11027), isolated from soil by virtue of its ability to grow on L-threonine as sole source of carbon and nitrogen (Bell et al., 1972), was observed to produce the water-insoluble purple pigment iodinin (phenazine-l,6-diol 5,lO-dioxide) during growth on L-threonine or glycine media (Bell & Turner, 1973). Evidence was obtained that iodini...

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The structural biology of phenazine biosynthesis.

The phenazines are a class of over 150 nitrogen-containing aromatic compounds of bacterial and archeal origin. Their redox properties not only explain their activity as broad-specificity antibiotics and virulence factors but also enable them to function as respiratory pigments, thus extending their importance to the primary metabolism of phenazine-producing species. Despite their discovery in t...

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Inhibition of photophosphorylation by phenazine methosulfate.

Phenazine methosulfate was shown to be a competitive inhibitor of H+ in light-induced H+ transport as well as a competitive inhibitor of orthophosphate in photophosphorylation. Similarly, H+, NH4+, and Pi in the presence of adenosine diphosphate were shown to inhibit competitively light-induced binding of phenazine methosulfate to chloroplasts. Pi, in the absence of ADP or other anions such as ...

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Structure of the phenazine biosynthesis enzyme PhzG.

PhzG is a flavin-dependent oxidase that is believed to play a role in phenazine antibiotic synthesis in various bacteria, including Pseudomonas. Phenazines are chorismic acid derivatives that provide the producing organisms, including the opportunistic pathogen P. aeruginosa, with a competitive growth advantage. Here, the crystal structures of PhzG from both P. aeruginosa and P. fluorescens sol...

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ژورنال

عنوان ژورنال: eLife

سال: 2020

ISSN: 2050-084X

DOI: 10.7554/elife.62983