منابع مشابه
Human telomerase exists in two distinct active complexes in vivo.
Telomerase, a stable complex of telomerase reverse transcriptase (TERT) and template RNA (TERC), is responsible for telomere maintenance. During purification trials of recombinant human telomerase of the two components reconstituted in insect cells, we identified two complexes of human telomerase of molecular masses 680 and 380 kDa, both of which retain telomerase activity in vitro. We show her...
متن کاملHuntingtin Exists as Multiple Splice Forms in Human Brain.
BACKGROUND A CAG repeat expansion in HTT has been known to cause Huntington's disease for over 20 years. The genomic sequence of the 67 exon HTT is clear but few reports have detailed alternative splicing or alternative transcripts. Most eukaryotic genes with multiple exons show alternative splicing that increases the diversity of the transcriptome and proteome: it would be surprising if a gene...
متن کاملHuman erythroid porphobilinogen deaminase exists in 2 splice variants.
Human porphobilinogen deaminase (PBGD) is, reportedly, encoded by 2 distinct messenger RNAs (mRNAs) transcribing from a single gene. The ubiquitous form of the PBGD gene product is often used as an endogenous reference in gene expression studies because it is pseudogene free and has minimal transcriptional variability among tissues. A distinct erythroid-specific gene product has also been descr...
متن کاملDOES HIPPOCAMPAL THETA EXISTS IN THE HUMAN BRAIN? (Comment
The hidden surface of the human medial temporal lobe (MTL) and its inaccessibility by traditional EEG recording procedures produced a large gap between human and animal data regarding hippocampal activity patterns. A wide-range of state-specific activity patterns of the hippocampal formation were established in animal studies, but few of them were unambiguously detected in humans. Two papers of...
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The nasal cavity possesses many advantages as a site for drug delivery, such as, ease of administration, applicability for long term treatments and a large surface area for absorption. One important limiting factor for nasal drug delivery is the limited time available for absorption within the nasal cavity due to mucociliary clearance. Several drug delivery systems including different kinds of ...
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ژورنال
عنوان ژورنال: Allergology International
سال: 2016
ISSN: 1323-8930
DOI: 10.1016/j.alit.2016.01.007