Fighting paralysis and dementia: Acetylcholinesterase inhibitors and reactivators in therapy
نویسندگان
چکیده
منابع مشابه
[Use of acetylcholinesterase inhibitors and memantine in Alzheimer-type dementia].
BACKGROUND The therapeutic options to treat Alzheimer-type dementia (ATD) in recent years, have made it increasingly necessary to become familiar with the employment pattern of these new medicinal products. METHODS A cross-sectional observational study of the population with ATD treated with acetylcholinesterase inhibitors and/or memantine in the Gallician Health Service. Databases were compi...
متن کاملIsolation and characterization of acetylcholinesterase inhibitors from Piper longum L.
Background and objectives: The cholinergic deficit correlates with the severity of Alzheimer’s disease. The cholinergic function can be improved by AChE inhibitors blocking this key enzyme in the breakdown of acetylcholine. Based on traditional medicine, during two last decades the use of herbal medicinal substances in dementia therapy has been studied. The fruit extract of <em...
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پژوهش حاضر در چارچوب مکتب دستکاری قرار گرفت و با استفاده از تقسیم بندی دوکات (2007) از شیوه های دستکاری، به دنبال یافتن پاسخ برای پرسش های زیر بود: 1-رایج ترین شیوه دستکاری در دوبله فیلم ها کدام است؟ 2-رایج ترین شیوه دستکاری در زیرنویس فیلم ها کدام است؟ 3-دستکاری در دوبله فیلم ها رایج تر است یا در زیرنویس آن ها؟ این پژوهش از نوع تحقیقات توصیفی- مقایسه ای و پیکره ای می باشد. پیکره تحقیق شا...
Docking Studies, Synthesis, and In-vitro Evaluation of Novel Oximes Based on Nitrones as Reactivators of Inhibited Acetylcholinesterase
Acetylcholinesterase has important role in synaptic cleft. It breaks down the acetylcholineatcholinergic synapsesand terminates the cholinergic effects. Some chemical agents likeorganophosphorus compounds (OPCs) including nerve agents and pesticides react withacetylcholinesteraseirreversibly. They inhibit normal biological enzyme action and resultin accumulation of acetylcholineand show toxic e...
متن کاملTargeting acetylcholinesterase and butyrylcholinesterase in dementia.
The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain acetylcholinesterase (AChE) has been the major therapeutic target of ChE-I treatment strategies for Alzheimer's disease (AD). AChE-positive neurons project diffusely to the cortex, modulating cortical processing and response...
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ژورنال
عنوان ژورنال: The Biochemist
سال: 2010
ISSN: 0954-982X,1740-1194
DOI: 10.1042/bio03204018