Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells
نویسندگان
چکیده
منابع مشابه
Oxidative stress alters global histone modification and DNA methylation
The JmjC domain-containing histone demethylases can remove histone lysine methylation and thereby regulate gene expression. The JmjC domain uses iron Fe(II) and α-ketoglutarate (αKG) as cofactors in an oxidative demethylation reaction via hydroxymethyl lysine. We hypothesize that reactive oxygen species will oxidize Fe(II) to Fe(III), thereby attenuating the activity of JmjC domain-containing h...
متن کاملThe Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach
The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories including nucleosome remodeling and RNA mediated targeting have been strongly investigated recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the tumorogenesis and cancer progression. Moreover...
متن کاملInterplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development.
Genes constitute only a small proportion of the mammalian genome, the majority of which is composed of non-genic repetitive elements including interspersed repeats and satellites. A unique feature of the mammalian genome is that there are numerous tissue-dependent, differentially methylated regions (T-DMRs) in the non-repetitive sequences, which include genes and their regulatory elements. The ...
متن کاملdna methylation and histone acetylation patterns in cultured bovine adipose tissue-derived stem cells (badscs)
objective: many studies have focused on the epigenetic characteristics of donor cells to improve somatic cell nuclear transfer (scnt). we hypothesized that the epigenetic status and chromatin structure of undifferentiated bovine adipose tissue-derived stem cells (badscs) would not remain constant during different passages. the objective of this study was to determine the mrna expression pattern...
متن کاملAnalysis of DNA methylation and histone modification profiles of liver-specific transporters.
Tissue-specific expression of transporters is tightly linked with their physiological functions through the regulation of the membrane transport of their substrates. We hypothesized that epigenetic regulation underlies the tissue-specific expression of mouse liver-specific transporters (Oatp1b2/Slco1b2, Ntcp/Slc10a1, Bsep/Abcb11, and Abcg5/g8). We examined their DNA methylation and histone modi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21061941