Field test and sensitivity of Onchocerciasis rapid test in Ogun State, Nigeria

Objective: This study, conducted between March 2015 and July 2016, investigated the sensitivity specificity of OV-16 RDT Dried Blood Spot (DBS) Enzyme-Linked Immunosorbent Assay (ELISA) for skin snip microfilaria (MF) detection in Ogun State.
 Methods: Five hundred eighty-eight (588) members 16 first-line communities 8 endemic Local Government Areas (LGAs) provided fingerstick whole blood specimens examined IgG4 antibodies against O. volvulus antigen OV-16, using DBS ELISA RDT. In consort with these specimens, 162 study participants consented to be evaluated by snip.
 Results: Results showed a seroprevalence 106(18.0%) 102(17.3%) RDT, 92.2% agreement. The demonstrated positive negative agreement 76.4 (95% CI 67.2 84.1%) 95.6% CI: 93.4 97.3), respectively, results from concordant dataset. Against 64 snips microscopy results, was 79.7% 73.43% 85.27) 70.3% 64.72% 75.37%).
 Conclusion: this information on performance will contribute data comparison studies other areas where treatment is ongoing. conclusion, commercial launch has made available point-of-care diagnostic tool that could serve help local country onchocerciasis elimination programs measure changes progress intervention.