Fibrosis Resulting from Dust Inhalation

Factors Affecting the Inhalation Dose from Tritiated Dust and Flakes . Factors Affecting the Inhalation Dose from Tritiated Dust and Flakes

Nanotechnology approaches for inhalation treatment of fibrosis

Cystic fibrosis (CF) is an autosomal recessive monogenetic disease that afflicts nearly 70,000 patients worldwide. The mutation results in the accumulation of viscous mucus in multiple organs especially in the lungs, liver and pancreas. High associated morbidity and mortality is caused by CF due to the lack of effective therapies. It is widely accepted that morbidity and mortality caused by CF ...

Inhalation of antibiotics in cystic fibrosis.

Aerosol administration of antipseudomonal antibiotics is commonly used in cystic fibrosis. However, its contribution to the improvement of lung function, infection and quality of life is not well-established. All articles published from 1965 until the present time concerning the inhalation of antibiotics in cystic fibrosis were collected by computerized literature search and analysed. Effective...

Fate of Pathologically Bound Oxygen Resulting from Inhalation of Labeled Ozone in Rats

Inhaled ozone (O3) reacts chemically with respiratory tract biomolecules where it forms covalently bound oxygen adducts. We investigated the fate of these adducts following inhalation exposure of rats to labeled ozone ((18)O3, 2 ppm, 6 hr or 5 ppm, 2 hr). Increased (18)O was detected in blood plasma at 7 hr post exposure and was continuously present in urine for 4 days. Total (18)O excreted was...

Inhalation risk and particle size in dust and mist.

Respiratory Absorption and Elimination The human respiratory system has long been known to filter the air passing through it. Lord Lister demonstrated that putrefactive organisms were not present in air passing out of the lungs and in 1869 Tyndall (1881) found that air expelled towards the end of a breath failed to produce scattered light near the focus of a light beam and caused the white trac...