Fibronectin: extra domain brings extra risk?
نویسندگان
چکیده
منابع مشابه
Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy
Liver sinusoidal endothelial cells (LSECs) are the main endothelial cells in the liver and are important for maintaining liver homeostasis as well as responding to injury. LSECs express cellular fibronectin containing the alternatively spliced extra domain A (EIIIA-cFN) and increase expression of this isoform after liver injury, although its function is not well understood. Here, we examined th...
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The identification of breast tumor initiating cells (BTICs) is important for the diagnosis and therapy of breast cancers. This study was undertaken to evaluate whether the extra domain-B of fibronectin (EDB-FN) could be used as a new biomarker for BTICs and whether EDB-FN targeting superparamagnetic iron oxide nanoparticles (SPIONs) could be used as a magnetic resonance imaging (MRI) contrast a...
متن کاملThe extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4.
The activation of mast cells by extra domain A of fibronectin (FN-EDA), an endogenous ligand of TLR4, and its contribution to the pathogenesis of rheumatoid arthritis (RA) in vivo were examined. FN-EDA, but no other domain of the fibronectin fragment, III(11) (FN-III(11)) and III(12) (FN-III(12)), stimulated bone marrow-derived murine mast cells (BMMCs) dose-dependently to secret cytokines (TNF...
متن کاملAdsorbers for Selective Removal of Extra Domain A-fibronectin from Patient Plasma
In patients with collagen diseases such as rheumatoid arthritis and systemic lupus erythematosus, immune complexes circulate in the blood deposits on tissues, causing inflammation, sclerosis, and deformable symptoms accompanying joint pain. These complexes form cryogels on cooling and can be removed by cryofiltration therapy. Fibronectin in the blood is a mediator of vascular inflammation and i...
متن کاملExpression of extra domain A fibronectin sequence in vascular smooth muscle cells is phenotype dependent
Different fibronectin (FN) variants arise from the single gene transcript alternatively spliced in a tissue-specific manner (Hynes, R. O. 1985. Annu. Rev. Cell Biol. 1:67-90; Owens, R. J., A. R. Kornblihtt, and F. E. Baralle. 1986. Oxf. Surv. Eurcaryotic Genes. 3:141-160). We used mAb IST-9, specific for extra domain A (ED-A) FN sequence, and cDNA probe to ED-A exon to determine whether ED-A is...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2015-03-630855