منابع مشابه
Fibroblast Growth Factor-1 vs. Fibroblast Growth Factor-2 in Ischemic Skin Flap Survival in a Rat Animal Model
BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...
متن کاملPotent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.
We describe here the identification and characterization of 2 novel inhibitors of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases. The compounds exhibit selective inhibition of FGFR over the closely related VEGFR2 receptor in cell lines and in vivo. The pharmacologic profile of these inhibitors was defined using a panel of human tumor cell lines characterized fo...
متن کاملTherapeutic Discovery Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models
We describe here the identification and characterization of 2 novel inhibitors of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases. The compounds exhibit selective inhibition of FGFR over the closely related VEGFR2 receptor in cell lines and in vivo. The pharmacologic profile of these inhibitors was defined using a panel of human tumor cell lines characterized fo...
متن کاملFibroblast Growth Factor
In an effort to elucidate control mechanisms for developmentally programmed cell death, conditions were sought which rescue the cells destined to die. Three areas of mesodermal cell death in the chick wing were examined, the posterior necrotic zone (PNZ) , the opaque patch (OP) and apical mesoderm. The PNZ and OP are areas of normally programmed cell death whereas the apical mesoderm undergoes ...
متن کاملThe fibroblast growth factor family.
Acidic and basic fibroblast growth factors are structurally related monomeric proteins which have been purified from a diverse set of vertebrate tissues. These prototype FGFs2 are mitogenic toward a broad spectrum of mesodermand ectoderm-derived cells and can also serve as trophic factors and as mediators of developmental pathways in a variety of in vitro and in vivo systems. Within the past 3 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2010
ISSN: 1556-0864
DOI: 10.1097/01.jto.0000391364.18141.9d