Fibroblast Growth Factor 23, Cardiovascular Disease, and Inflammation
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor 23 and Inflammation in CKD.
BACKGROUND AND OBJECTIVES Levels of fibroblast growth factor 23 (FGF23) and inflammatory markers are commonly elevated in CKD, and each is associated with adverse clinical outcomes. This study tested the hypothesis that FGF23 is independently associated with inflammation in CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The association between levels of FGF23 and the inflammatory markers ...
متن کاملAlcoholism, Fibroblast Growth Factor 23 and Cardiovascular Risk
Main Findings: Hyperphosphatemia constitutes a major stimulus for FGF-23 secretion, together with infl ammation and reduced iron availability, either by iron defi ciency or by iron sequestration in infl ammatory diseases. FGF-23 can be expressed by the damaged liver. Alcoholism is a proinfl ammatory condition, and in alcoholics there is an increased cardiovascular risk. Preliminary data suggest...
متن کاملFibroblast growth factor 23: roles in health and disease.
A lthough phosphate is important in skeletal mineralization, energy metabolism, and multiple enzymatic processes, little has been understood about the regulation of phosphate in health and disease until recently. Genetic and acquired disorders of phosphate homeostasis have begun to reveal important mechanisms for the regulation of phosphate metabolism. Candidate phosphate-regulating hormones (“...
متن کاملFibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.
Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk of mortality. Increases in inflammatory markers are another common feature that predicts poor clinical outcomes. Elevated FGF23 is associated with higher circulating levels of inflammatory cytokines in CKD, which can s...
متن کاملUpdate on Fibroblast Growth Factor 23 in Chronic Kidney Disease
Chronic kidney disease (CKD) is a public health epidemic that affects millions of people worldwide. Presence of CKD predisposes individuals to high risks of end-stage renal disease (ESRD), cardiovascular disease, and premature death. Disordered phosphate homeostasis with elevated circulating levels of fibroblast growth factor 23 (FGF23) is an early and pervasive complication of CKD. CKD is like...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2012
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.05500512