Fibroblast Growth Factor 1 Gene and Hypertension

Fibroblast Growth Factor-1 vs. Fibroblast Growth Factor-2 in Ischemic Skin Flap Survival in a Rat Animal Model

BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...

Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis.

BACKGROUND The distal portion of the long arm of chromosome 5 is linked to hypertension and contains functional candidate blood pressure-regulating genes. METHODS AND RESULTS Tightening the grid of microsatellite markers under this quantitative trait locus in the Silesian Hypertension Study (629 individuals from 207 Polish hypertensive families) provided enhanced support for linkage of this r...

Fibroblast Growth Factor-1 (FGF-1)

Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells

Fibroblast growth factor (FGF) and type beta transforming growth factor (TGF beta) are potent modulators of proliferation and differentiation in many types of cells. TGF beta acts in an autocrine manner, and the regulation of TGF beta gene expression is one of the crucial events in the control of cellular functions. This study examines FGF regulation of TGF beta 1 gene expression in osteoblast-...

Fibroblast Growth Factor Enhances Type/?1 Transforming Growth Factor Gene Expression in Osteoblast-like Cells

Fibroblast growth factor (FGF) and type/3 transforming growth factor ('rGF/3) are potent modulators of proliferation and differentiation in many types of cells. TGF/~ acts in an autocrine manner, and the regulation of TGF/3 gene expression is one of the crucial events in the control of cellular functions. This study examines FGF regulation of TGF/31 gene expression in osteoblast-like cells. Bov...