Fibrin Modulates Shear-Induced NETosis in Sterile Occlusive Thrombi Formed under Haemodynamic Flow
نویسندگان
چکیده
منابع مشابه
Occlusive auricular thrombi.
The literature on occlusive thrombi of the auricles has been reviewed in order to identify the symptom complex attributed to this condition. The clinicopathological findings are presented in four new cases which fit this symptom complex. Two cases are notable in that one is that of a ball thrombus occurring in the absence of mitral stenosis and another the first reported case of pedunculated th...
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Blood clots are made up of platelets and fibrin gel, and the relative amount of fibrin is strongly influenced by the shear rate. In order to explore this phenomenon, this paper presents a model of fibrin gel formation over the surface of an injured blood vessel in a shear flow. A condition for gelation including source and sink terms of polymer is derived. A simplified model of coagulation, inv...
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The 4 integrin, 4 7, plays an important role in recruiting circulating lymphocytes to the gastrointestinal tract, where its ligand mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is preferentially expressed on high endothelial venules (HEVs). Dual antagonists of 4 1 and 4 7, N-(2,6-dichlorobenzoyl)-(L)-4-(2 ,6 -bis-methoxyphenyl)phenylalanine (TR14035) and N-{N-[(3,5-dichlorobenzene)sulfo...
متن کاملHindered dissolution of fibrin formed under mechanical stress
BACKGROUND Recent data indicate that stretching forces cause a dramatic decrease in clot volume accompanied by gross conformational changes of fibrin structure. OBJECTIVE The present study attempts to characterize the lytic susceptibility of fibrin exposed to mechanical stress as a model for fibrin structures observed in vivo. METHODS AND RESULTS The relevance of stretched fibrin models was...
متن کاملStructure and mechanics of fibrin clots formed under mechanical perturbation.
darone withdrawal can lead to under-anticoagulation, and therefore to an increased risk of thrombosis. In conclusion, we describe the first case of genetic VKA resistance in a child who had the p.Asp36Tyr mutation combined with g. 1185G>A and g. 679A>G mutations in the 5′-flanking region. VKA resistance was partially masked initially by concomitant amiodarone therapy. Both warfarin–drug interac...
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ژورنال
عنوان ژورنال: Thrombosis and Haemostasis
سال: 2019
ISSN: 0340-6245,2567-689X
DOI: 10.1055/s-0039-1678529