Fiber Bragg Grating Sensors-Based Thermometry of Gold Nanorod-Enhanced Photothermal Therapy in Tumor Model

This work proposes the use of femtosecond laser-written fiber Bragg grating (FBG) sensors for internal temperature monitoring tumors undergoing gold nanorod (AuNR)-mediated photothermal therapy (PTT). Arrays sub-millimetric FBGs enabled an accurate and quasi-distributed measurement within subcutaneous breast in mice. Furthermore, permitted to investigate laser-tissue interaction AuNR-assisted enhancement on cancerous tissue exposed 940 nm 1064 radiations. The introduction tumor-localized AuNRs resulted overall increase 13 °C mean change, compared control, case nm, while ~6 nm. sensing solution allows minimally invasive tumor under PTT. feasibility study sets basis evaluation thermal outcome mediated by nanoparticles different laser sources.